Machine Learning Scientist – Clinical Prediction

We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. In this role, you will design and implement clinical fine-tuning of Enchant, our multimodal transformer model trained on a wide variety of biomedical data, pushing the boundaries of what large-scale foundation models can achieve in drug discovery.

This role spans data sourcing through to production deployment. You will identify, curate, and evaluate datasets that support prediction of relevant clinical endpoints (patient- and trial-level outcome modeling, safety/toxicity prediction, and PK/PD response modeling) and fine-tune Enchant to deliver critical clinical insights. This includes developing rigorous, leakage-resistant experimental frameworks, optimizing training, orchestrating runs at scale, and working with colleagues across ML and clinical functions to put these models into the hands of scientists making real therapeutic decisions.

• Fine-tune large-scale multimodal transformer models for clinical and biomedical applications
• Identify, characterize, and utilize datasets that can deliver insights into pharmacokinetics (PK), pharmacodynamics (PD), toxicity, clinical adverse events, and clinical trial outcomes
• Develop and apply rigorous experimental approaches that account for multiple sources of potential leakage (split, metadata, trial-family, temporal, ontological, arm-comparator, etc.)
• Design and maintain benchmarking and evaluation frameworks that track model quality across models and tasks
• Build models with appropriate calibration, uncertainty quantification, and clinically meaningful evaluation metrics.
• Collaborate with ML and software engineering colleagues to deploy and operationalize models
• Partner with clinical scientists and pharmacologists to ensure model development is grounded in drug discovery and development needs
• Communicate results to internal teams, external partners, and at conferences
• Generate high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity

• MS in chemistry, bio/chemical engineering, or a computational STEM field with 3+ years of relevant industry or research experience, or PhD or equivalent industry experience demonstrating comparable depth
• Strong Python experience, including implementing and fine-tuning deep learning models
• Demonstrated experience in clinical science or working with clinical datasets
• Excellent Data Science skills (problem framing, data sourcing, extraction, cleaning, visualization, EDA, modeling, tuning, storytelling, etc.)
• Enough independence to own a workstream from data ingestion through evaluation
• Strong engineering habits: reproducible experimentation, appropriate control strategy, clean code, testing
• Comfort working with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking such as Weights & Biases)

• Experience building and deploying clinically relevant prediction models
• Familiarity with ClinicalTrials.gov/AACT http://ClinicalTrials.gov/AACT data
• Experience with MedDRA, pharmacovigilance, or adverse event data
• Direct exposure to multi-task learning
• Hands-on experience with agentic data extraction
• HPC or large-scale computing experience

Our mission is to make better technology for better medicines. Three values guide how we work:

• Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity.
• Innovative. We are creative and find new solutions that deliver impact.
• Collaborative. We respect one another and partner with integrity.

We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow.

The pay range for this role is listed above. Actual pay depends on factors including experience, skills, and location. Eligible employees in the U.S. receive company-paid medical coverage, flexible spending accounts, voluntary life insurance, 401(k) matching and flexible time off. We are in a brand-new state-of-the art facility in beautiful San Diego with a community gym, dining, and easy access to great places to live and play.

Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at iambic.ai http://iambic.ai.