Amylyx Pharmaceuticals, Cambridge, MA +1
Amylyx is seeking an experienced and innovative Senior Director, Clinical Systems to join our Clinical Operations organization. This newly created role will be responsible for advancing clinical systems capabilities needed to support Amylyx’s evolving clinical development portfolio, in collaboration with Information Technology, Quality and other functions.
As Amylyx expands its internal Clinical Operations capabilities to accommodate a variety of outsourced operating models, our clinical technology and internal working procedures must evolve to support this shift. The Senior Director, Clinical Systems will partner with IT and Clinical Operations, playing a critical role in defining the systems, tools, data, and processes that enable efficient, compliant, and data-driven clinical trial execution.
Reporting to the Vice President, Clinical Compliance & Systems, this individual will partner with IT and Clinical Operations to translate strategy and business needs into a scalable clinical systems roadmap. The role will initially have significant focus on enabling CTMS capabilities, improved cross-study reporting and visibility, and development of the comprehensive operational ecosystem required to support these processes and systems over time. This individual will also partner with Information Delivery to identify opportunities to evolve process through use of AI and other automation/analytic platforms.
This is an opportunity for a hands-on, forward-thinking clinical leader who enjoys building capabilities, solving complex operational challenges, and identifying thoughtful ways to use technology, automation, analytics, and emerging tools to improve how clinical development work gets done.
$252,000—$283,000 USD
To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn.
To return to our website please click here.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.
Base salary is one component of Amylyx’s total rewards package. In addition to competitive base pay, eligible employees may receive annual performance-based bonuses and equity awards, providing an opportunity to share in the company’s long-term success. Amylyx also offers a comprehensive benefits package designed to support the health, well-being, and financial security of our employees.
Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).
Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.
Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances.
Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
Pay not posted
Posted Oct 9, 2026
Praxis Precision Medicines, Inc. United States - Remote
$205K–$229K / yr
Posted Sep 24, 2026
AbCelleraVancouver
CA$120K–CA$152K / yr
Posted 19 days ago
Axsome TherapeuticsNew York, NY +1
$145K–$160K / yr
Posted 8 days ago
Amyris, Inc.Emeryville
$103K–$131K / yr
Posted Oct 2, 2026
Corcept TherapeuticsRedwood City, California +1
$194K–$228K / yr
Posted Oct 15, 2026
Source: the Amylyx Pharmaceuticals Greenhouse job board. We last checked this job 9 h ago. We first saw it 8 days ago. A job on a job board does not always mean that the team interviews people now. We found this job board in a public list. We did not yet compare it with the careers page of the company.
No one has reported an interview at Amylyx Pharmaceuticals yet. Did you interview there? Add the questions.
This base pay is above the median for director-level infrastructure, platform and SRE jobs in other US places.
We compare the middle of each posted range. This is base pay as posted. The group does not include this job.