ML Research Scientist - Computational Biophysics

Our Bio team designs, builds, and characterizes the biotechnologies that form the foundation of next-generation brain-computer interfaces. We combine molecular engineering, synthetic biology, neuroscience and advanced physical methods such as ultrasound to establish less invasive, high-bandwidth connections with neurons. The Bio team develops our core molecular technologies, validates their performance in vitro and in vivo, and demonstrates their advanced capabilities in animal models.

We build custom experimental setups and pipelines and collaborate closely with engineers and data scientists. We work across disciplines to come up with creative ideas and solve some of the most challenging problems in biotechnology.

• Build the scientific and engineering scaffolding for protein structure modeling, molecular dynamics, and integrations with downstream ML frameworks.
• Collaborate with wet-lab scientists to define tractable optimization objectives and encode domain specific priors and constraints.
• Prototype modeling frameworks using internal and public datasets; benchmark and validate performance.
• Serve to non-domain experts for democratization of first-principles analysis
• Drive the development of ML frameworks that explicitly incorporate first-principles priors.
• Stay up-to-date with the latest research in deep-learning, molecular dynamics, and protein structure modeling and prototype novel algorithms that can be deployed to improve the company’s discovery or development workflows.
• Contribute to the long-term research roadmap and serve as a thought-leader for scientists.

• Strong grounding in deep-learning, protein-structure modeling, and molecular dynamics.
• Working knowledge of transfer-learning strategies
• Proficiency in Python / PyTorch / Jax and comfort writing clean, reproducible production grade code.
• Experience bridging machine learning and experimental science–working with sparse, noisy, and or high-cost data.
• A collaborative, systems-level mindset.

• Familiarity with neuroscience.
• Familiarity with language / state-space models.

If you're excited about this role but don't meet every qualification, please apply. As we build, we're hiring for complementary strengths to form a high-impact team.

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Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability, agency and experience. We’re pursuing this goal by developing fundamentally new approaches to brain-computer interfaces that interact with the brain at high bandwidth, integrate with advanced AI, and are ultimately safe and accessible for anyone to use.