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Senior / Staff Cloud Platform Engineer (ML)

Calico , South San Francisco, CA

Posted pay

$220K–$290K

a year

Location: South San Francisco, CA
Work type: Not given
Level: Staff
Experience: 7+ years
Skills in the job text: Python
Kubernetes
GCP
Docker
Go
Terraform
Posted: Jul 15, 2026
Last check: 20 min ago
Job type: ML / AI engineering, Inference & ML systems

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Calico

About Calico : funding, hiring and pay

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The role

Calico seeks a Senior / Staff Cloud Engineer to lead the execution and operation of our next-generation machine learning (ML) platform. As the technical authority for our Google Cloud Platform (GCP) environment, you will build infrastructure-as-Code (IaC), design secure perimeters, automate identity management, and migrate existing workflows into a unified, compliant infrastructure.

If you are passionate about DevSecOps, IaC, and building "paved paths" that empower scientists while enforcing rigorous security, this is the role for you. You will be the critical bridge that allows our ML Systems and Research engineers to train and deploy ML models for frontier BioML research.

Please note: No biology or life sciences background is required for this role.

What you will do

You will work with a team of researchers and engineers on Calico’s key strategic cross-functional initiatives through the following responsibilities:

Foundational Impact:
Deliver our next-generation ML platform
Lead the consolidation and modernization of our compute environments, and accelerate the whole company's R&D cycle
GCP Foundation:
Lead the centralization of GCP projects into a unified, compliant landing zone
Design secure perimeters to protect sensitive biological data, and build automated guardrails using Terraform
GKE Cluster Administration:
Design, deploy, and maintain robust GKE clusters tailored for distributed ML training and batch processing workloads
Troubleshoot node-level GPU/TPU issues, manage scheduling add-ons, and optimize cluster autoscaling
Developer Experience & Onboarding:
Design intuitive onboarding processes and "paved paths" for scientists to seamlessly onboard onto the new platform
FinOps:
Manage org-level GPU/TPU compute capacity, implement centralized billing and cost reporting, and build comprehensive monitoring dashboards to track cluster utilization and optimize R&D expenditure

What you need

BS/MS with 7+ years or PhD with 4+ years of relevant software engineering, DevSecOps, or Cloud architecture experience
Strong programming skills in Python
Strong hands-on experience with Google Cloud Platform (GCP) core services
Experience with Kubernetes cluster administration
Experience with Terraform, building CI/CD pipelines, and containerization (Docker)
Must be willing to work onsite at least four days a week

Nice to have

A strong intellectual curiosity for life sciences
Experience managing Kubernetes for HPC or ML workloads
Experience supporting Machine Learning orchestration and queueing frameworks (e.g., Kueue, Ray)
Experience reading and debugging ML Python code
Experience implementing compliant cloud architectures (e.g., SOC2, HIPAA, or similar frameworks)
Familiarity with Golang
Strong communication skills with a proven ability to guide users through migration

The estimated base salary range for this role is $220,000 - $290,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

About Calico

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Read the job posting on the Calico site

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Source: the Calico Greenhouse job board. We last checked this job 20 min ago. We first saw it 5 days ago. A job on a job board does not always mean that the team interviews people now. We found this job board in a public list. We did not yet compare it with the careers page of the company.

Calico

Open tech jobs: 3
With posted pay: 100%

About Calico : funding, hiring and pay

Compared with similar jobs

This base pay is near the median for staff ML and AI engineering jobs in the Bay Area.

Median: $265K a year
Other jobs in the group: 222

We compare the middle of each posted range. This is base pay as posted. The group does not include this job.